Computational biology · Bioinformatics

Alen Zimic-Sheen

I am from Peru and hold a B.Sc. in Environmental Engineering. My research experience includes bioinformatics and computational biology, and I will begin a PhD in Computational Biology at Cornell University in August 2026.

Portrait of Alen Zimic-Sheen outdoors

Methods

Computational methods

About

Background

I am from Peru and hold a B.Sc. in Environmental Engineering from Universidad Peruana Cayetano Heredia. My research experience includes bioinformatics, computational biology, environmental biotechnology, and molecular biology.

In the Moghe Lab at Cornell University, I work on computational methods for literature mining and gene-function research. Earlier projects in Peru and at UC Berkeley/USDA included metagenomics, protein modeling, immunoinformatics, plant–microbe interactions, and synthetic biology.

In August 2026, I will begin a PhD in Computational Biology at Cornell University with support from the SUNY Fellowship.

Experience

Research experience

Ithaca, NY

Aug 2025 - Current

Laboratory Technician

Plant Science Department, Cornell University - PI: Gaurav Moghe, PhD

Current focus

Building computational workflows in the Moghe Lab as part of the C-SPIRIT research team, connecting uncharacterized plant metabolites with genes, tissues, species, and stress-related traits.

  • LLMs
  • Plant Metabolites
  • Graph Neural Networks
  • Python
  • Jan 2025 - May 2025

    Visiting Student Researcher

    Plant Gene Expression Center, UC Berkeley - USDA - PI: Devin Coleman-Derr, PhD

    Studied drought-associated plant-microbe interactions in sorghum, connecting greenhouse work, RNA extraction, phenotyping, and Streptomyces genomics.

  • Jun 2021 - Jan 2025

    Research Assistant

    Bioinformatics and Molecular Biology Laboratory, UPCH - PIs: Mirko Zimic, PhD and Patricia Sheen, PhD

    Worked across pathogen bioinformatics, antigen modeling, metagenomics, and molecular biology platforms in a lab spanning health and environmental applications.

  • Jan 2024 - Jan 2025

    Bachelor's Thesis Researcher

    Laboratory of Functional Genomics, UPCH - PI: Luis De-Stefano, PhD

    Built a field-to-sequencing workflow to study how biofertilizer treatments may shift avocado rhizosphere microbiomes.

  • Sep 2023 - Jan 2025

    Research Assistant

    Laboratory of Andean-Amazonian Chemistry of Life, UPCH - PI: Denis Castillo, PhD

    Developed and analyzed biodegradable hydrogels as a controlled-release approach for agricultural nitrogen management.

Publications

Selected publications

View full CV
2025 Enrichment of root-associated Streptomyces strains in response to drought is driven by diverse functional traits and does not predict beneficial effects on plant growth PLOS Biology A strain-level view of drought-enriched Streptomyces in sorghum roots, showing that enrichment and plant-growth benefit do not map cleanly onto the genus as a whole. 2026 Rapid and cost-effective fabrication of microfluidic chips with resin 3D printing Progress in Additive Manufacturing A practical evaluation of resin 3D printing as a lower-cost route for prototyping PDMS microfluidic templates. 2025 A simple and low-cost electrode based on Nafion-stabilized silver nanoparticles supported on FTO for the electrochemical determination of Pb(II) and Cu(II) PLOS ONE A low-cost electrochemical sensing approach for detecting lead and copper ions using silver nanoparticles stabilized on FTO. 2023 An Open Hardware Bioprinter Part I: A bioextruder with a peristaltic pump approach IEEE Xplore An open-hardware bioextrusion design built around a peristaltic pump architecture for accessible bioprinting. 2023 Multiantigen print immunoassay (MAPIA) for the diagnosis of neurocysticercosis: a single-center diagnostic optimization and accuracy study in Lima, Peru Journal of Clinical Microbiology A diagnostic optimization study evaluating a multiantigen print immunoassay for neurocysticercosis in a Lima clinical setting.

Projects

Selected projects

GitHub profile

May 2026

ESM3 Transfer Learning for Enzyme–Substrate Prediction

Protein foundation-model representations for substrate-class prediction

A Cornell deep-learning course project using frozen ESM3 representations and downstream classifiers to study enzyme substrate classes and residue-level signals.

  • ESM3
  • Protein Language Models
  • Transfer Learning
  • Interpretability
View repository

Apr 2026

RoPE Visualized

Interactive rotary embeddings teaching demo

A static, dependency-free visual demo for teaching rotary positional embeddings, including real RoPE formulas and cosine-similarity comparisons.

  • Transformers
  • LLMs
  • Visualization
View repository

Apr 2026

Mentoring Workspace

Mentor-mentee collaboration tracker

Built for REU mentoring, this shared workspace helps mentor-mentee teams track notes, tasks, deadlines, and Google Docs/Sheets sync.

  • Mentoring
  • Research Training
  • Google Apps Script
View repository

Jun 2024

Eye Movement Feature Tracking

Computer vision for saccadic eye movement analysis

A small computer-vision workflow for tracking eye movement responses from video and extracting interpretable motion features.

  • Computer Vision
  • Python
  • Biomedical Signals
View repository

Apr–Jun 2024

Sketch Feature Classifier

Sketch feature classification with deep learning embeddings

A machine-learning experiment using learned image embeddings to classify sketch-derived visual features.

  • ResNet
  • KNN
  • Machine Learning
View repository

2026

Plant AI Training Repository

A practical AI tools guide for plant scientists

A companion repository for the Plant Cell review, collecting relevant AI tools and learning resources for plant scientists.

  • Plant Science
  • AI Tools
  • Training Resource
View repository

Education

Education

Beginning August 2026

PhD in Computational Biology

Cornell University

Incoming PhD student in Computational Biology at Cornell University, funded by the SUNY Fellowship.

2019 - 2024

B.Sc. in Environmental Engineering

Universidad Peruana Cayetano Heredia, Lima, Peru

Graduated with a GPA of 3.86 and ranked second in order of merit across the Environmental Engineering program.

Recognition

Funding, awards, and presentations

Selected support, awards, presentations, and public science.

Community

Service and mentoring

Selected roles in training, synthetic biology, and student leadership.

Nov 2025 - Present Cornell I-CIPS student co-lead Student co-lead for Cornell's Initiative for Computational Innovation in Plant Sciences.
Oct 2024 - 2026 iGEM Engineering Plan Committee member Nearly two years supporting the iGEM Engineering Plan Committee, with emphasis on plant-based synthetic biology projects.

Contact

Contact

For research or academic correspondence, please contact me by email.